"We are deeply saddened to announce today that our loved one, DMX, birth name of Earl Simmons, passed away at 50-years-old at White Plains Hospital with his family by his side after being placed on life support for the past few days," family's statement read in part.
The artist had been hospitalized since last week when he suffered a heart attack at his home in New York, according to his longtime attorney, Murray Richman.
DMX (Dark Man X) began rapping in the early 1990s and released his debut album, "It's Dark and Hell Is Hot," in 1998.
With the deaths of fellow rappers The Notorious B.I.G. and Tupac Shakur before he burst on the scene, DMX became one of the reigning stars of hardcore hip hop and was the premier artist signed to the Ruffhouse Records label.
His single, "Ruff Ryders Anthem," helped to seal his critical and commercial success.
The rapper released several albums over the years, including one of his most commercially successful, "...And Then There Was X," which was released in 1999 and was nominated for a Grammy in the best rap album category. It was one of three Grammy nominations for the rapper.
He sold millions of albums, boosted by hits like "Get At Me Dog" in 1998, "Party Up," in 1999, and "X Gon' Give It to Ya," in 2003.
He parlayed his growing fame into an acting career, appearing in multiple films including, "Romeo Must Die" and "Cradle 2 The Grave."
His professional achievements were often overshadowed by his issues with substance abuse and run-ins with the law. He pleaded guilty to tax fraud in 2017 and was sentenced to one year in prison.
In 2019, DMX canceled a planned concert tour to seek treatment for addiction, saying at the time that he was "putting family and sobriety first."
That same year he talked to GQ about his struggles.
"I just need to have a purpose," he said. "And I don't even know that purpose, because God has given me that purpose since before I was in the womb, so I'm going to fulfill that purpose ... whether I want to or not, whether I know it or not, because the story has already been written. If you appreciate the good, then you have to accept the bad."